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Discovery of virulence genes of Legionella pneumophila by using signature tagged mutagenesis in a guinea pig pneumonia model

Legionella pneumophila is the cause of Legionnaires’ disease, which is a form of potentially fatal pneumonia. To identify genes required for virulence of the bacterium, a library of 1,386 L. pneumophila signature tagged transposon mutants was studied for guinea pig virulence. The mutants were screen...

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Bibliografische gegevens
Hoofdauteurs: Edelstein, Paul H., Edelstein, Martha A. C., Higa, Futoshi, Falkow, Stanley
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22210/
https://ncbi.nlm.nih.gov/pubmed/10393970
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