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Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila
Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2220037/ https://ncbi.nlm.nih.gov/pubmed/18270582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001595 |
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