Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus

Previous studies have suggested that MHC and non-MHC genes contribute to the development of autoimmune disease in F(1) hybrids of New Zealand black (NZB) and white (NZW) mice. We conducted a genome-wide screen of 148 female (NZB × NZW)F(1) × NZB backcross mice to map dominant NZW genetic loci linked...

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Bibliographic Details
Main Authors: Vyse, Timothy J., Halterman, Richard K., Rozzo, Stephen J., Izui, Shozo, Kotzin, Brian L.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC22194/
https://ncbi.nlm.nih.gov/pubmed/10393954
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