Insight into the Neuroendocrine Site and Cellular Mechanism by which Cortisol Suppresses Pituitary Responsiveness to Gonadotropin-Releasing Hormone

Stress-like elevations in plasma glucocorticoids rapidly inhibit pulsatile LH secretion in ovariectomized sheep by reducing pituitary responsiveness to GnRH. This effect can be blocked by a nonspecific antagonist of the type II glucocorticoid receptor (GR) RU486. A series of experiments was conducte...

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Detalhes bibliográficos
Main Authors: Breen, Kellie M., Davis, Tracy L., Doro, Lisa C., Nett, Terry M., Oakley, Amy E., Padmanabhan, Vasantha, Rispoli, Louisa A., Wagenmaker, Elizabeth R., Karsch, Fred J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2219297/
https://ncbi.nlm.nih.gov/pubmed/17962347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-0773
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