Differential Effects of Tyrosine Kinase Inhibitors on Volume-sensitive Chloride Current in Human Atrial Myocytes: Evidence for Dual Regulation by Src and EGFR Kinases

To determine whether protein tyrosine kinase (PTK) modulates volume-sensitive chloride current (I(Cl.vol)) in human atrial myocytes and to identify the PTKs involved, we studied the effects of broad-spectrum and selective PTK inhibitors and the protein tyrosine phosphatase (PTP) inhibitor orthovanad...

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Main Authors: Du, Xin-Ling, Gao, Zhan, Lau, Chu-Pak, Chiu, Shui-Wah, Tse, Hung-Fat, Baumgarten, Clive M., Li, Gui-Rong
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217456/
https://ncbi.nlm.nih.gov/pubmed/15024039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409013
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