Constitutive activation of the G-protein subunit Gαs within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression

Memory formation requires cAMP signaling; thus, this cascade has been of great interest in the search for cognitive enhancers. Given that medications are administered long-term, we determined the effects of chronically increasing cAMP synthesis in the brain by expressing a constitutively active isof...

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Detalhes bibliográficos
Main Authors: Kelly, Michele P., Cheung, York-Fong, Favilla, Christopher, Siegel, Steven J., Kanes, Stephen J., Houslay, Miles D., Abel, Ted
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2216679/
https://ncbi.nlm.nih.gov/pubmed/18230676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.723708
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