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Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel

A series of n-alkyl-bis-alpha,omega-trimethylammonium (bisQn) compounds was synthesized, and their ability to block K+ currents through a K+ channel from sarcoplasmic reticulum was studied. K+ channels were inserted into planar phospholipid membranes, and single-channel K+ currents were measured in...

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Bibliografske podrobnosti
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1982
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2215508/
https://ncbi.nlm.nih.gov/pubmed/6284862
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