Autoimmune Th2-Mediated Dacryoadenitis in MRL/MpJ Mice Becomes Th1-Mediated in IL-4 Deficient MRL/MpJ Mice

PURPOSE: MRL/MpJ mice of substrains MRL/MpJ-fas(+)/fas(+) (MRL/+) and MRL/MpJ-fas(lpr)/fas(lpr) (MRL/lpr) spontaneously develop autoimmune dacryoadenitis and sialadenitis and are a model for the human disorder Sjögren syndrome. The dacryoadenitis in both substrains appears to be Th2 in nature, with...

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Main Authors: Jabs, Douglas A., Prendergast, Robert A., Campbell, Adam L., Lee, Bella, Akpek, Esen Karamursel, Gérard, Hervé C., Hudson, Alan P., Whittum-Hudson, Judith A.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2215323/
https://ncbi.nlm.nih.gov/pubmed/18055812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-0237
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