Oncogenic Ras-Induced Morphologic Change Is through MEK/ERK Signaling Pathway to Downregulate Stat3 at a Posttranslational Level in NIH3T3 Cells

Ras is a key regulator of the MAP kinase-signaling cascade and may cause morphologic change of Ras-transformed cells. Signal transducer and activator of transcription 3 (Stat3) can be activated by cytokine stimulation. In this study, we unravel that Ha-ras(V12) overexpression can downregulate the ex...

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Main Authors: Yeh, Hsuan-Heng, Wu, Chin-Han, Giri, Raghavaraju, Kato, Ken, Kohno, Kimitoshi, Izumi, Hiroto, Chou, Cheng-Yang, Su, Wu-Chou, Liu, Hsiao-Sheng
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213899/
https://ncbi.nlm.nih.gov/pubmed/18231638
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