Intrinsic Electrostatic Potential in the BK Channel Pore: Role in Determining Single Channel Conductance and Block

The internal vestibule of large-conductance Ca(2+) voltage-activated K(+) (BK) channels contains a ring of eight negative charges not present in K(+) channels of lower conductance (Glu386 and Glu389 in hSlo) that modulates channel conductance through an electrostatic mechanism (Brelidze, T.I., X. Ni...

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Main Authors: Carvacho, Ingrid, Gonzalez, Wendy, Torres, Yolima P., Brauchi, Sebastian, Alvarez, Osvaldo, Gonzalez-Nilo, Fernando D., Latorre, Ramon
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2008
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213566/
https://ncbi.nlm.nih.gov/pubmed/18227273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709862
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