Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells

The germinal center (GC) is an anatomic compartment found in peripheral lymphoid organs, wherein B cells undergo clonal expansion, somatic mutation, switch recombination, and reactivate immunoglobulin gene V(D)J recombination. As a result of somatic mutation, some GC B cells develop higher affinity...

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Autors principals: Meffre, Eric, Papavasiliou, Fotini, Cohen, Paul, de Bouteiller, Odette, Bell, Diana, Karasuyama, Hajime, Schiff, Claudine, Banchereau, Jacques, Liu, Yong-Jun, Nussenzweig, Michel C.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1998
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213359/
https://ncbi.nlm.nih.gov/pubmed/9705958
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