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Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

Systemic onset juvenile idiopathic arthritis (SoJIA) encompasses ∼10% of cases of arthritis that begin in childhood. The disease is unique in terms of clinical manifestations, severity of joint involvement, and lack of response to tumor necrosis factor blockade. Here, we show that serum from SoJIA p...

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Autors principals: Pascual, Virginia, Allantaz, Florence, Arce, Edsel, Punaro, Marilynn, Banchereau, Jacques
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213182/
https://ncbi.nlm.nih.gov/pubmed/15851489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050473
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