Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels

In this study, we identify the bidirectional organic cation transporter 3 (OCT3/Slc22a3) as the molecule responsible for histamine uptake by murine basophils. We demonstrate that OCT3 participates in the control of basophil functions because exogenous histamine can inhibit its own synthesis—and that...

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Detalhes bibliográficos
Main Authors: Schneider, Elke, Machavoine, François, Pléau, Jean-Marie, Bertron, Anne-France, Thurmond, Robin L., Ohtsu, Hiroshi, Watanabe, Takehiko, Schinkel, Alfred H., Dy, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213077/
https://ncbi.nlm.nih.gov/pubmed/16061728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050195
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