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Restricted MHC–peptide repertoire predisposes to autoimmunity
MHC molecules associated with autoimmunity possess known structural features that limit the repertoire of peptides that they can present. Such limitation gives a selective advantage to TCRs that rely on interaction with the MHC itself, rather than with the peptide residues. At the same time, negativ...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Rockefeller University Press
2005
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212910/ https://ncbi.nlm.nih.gov/pubmed/15998789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050198 |
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