Restricted MHC–peptide repertoire predisposes to autoimmunity

MHC molecules associated with autoimmunity possess known structural features that limit the repertoire of peptides that they can present. Such limitation gives a selective advantage to TCRs that rely on interaction with the MHC itself, rather than with the peptide residues. At the same time, negativ...

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Bibliographic Details
Main Authors: Logunova, Nadezda N., Viret, Christophe, Pobezinsky, Leonid A., Miller, Sara A., Kazansky, Dmitri B., Sundberg, John P., Chervonsky, Alexander V.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212910/
https://ncbi.nlm.nih.gov/pubmed/15998789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050198
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