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A severe defect in CRAC Ca(2+) channel activation and altered K(+) channel gating in T cells from immunodeficient patients

Engagement of the TCR triggers sustained Ca(2+) entry through Ca(2+) release-activated Ca(2+) (CRAC) channels, which helps drive gene expression underlying the T cell response to pathogens. The identity and activation mechanism of CRAC channels at a molecular level are unknown. We have analyzed ion...

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Detalhes bibliográficos
Main Authors: Feske, Stefan, Prakriya, Murali, Rao, Anjana, Lewis, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212870/
https://ncbi.nlm.nih.gov/pubmed/16147976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050687
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