11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

The enzyme 11β–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective glucocorticoid (GC) tone above serum levels. We report that pharmacologic inhibition of 11β-HSD1 has a therapeutic effect in mouse models of metabolic syn...

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Autori principali: Hermanowski-Vosatka, Anne, Balkovec, James M., Cheng, Kang, Chen, Howard Y., Hernandez, Melba, Koo, Gloria C., Le Grand, Cheryl B., Li, Zhihua, Metzger, Joseph M., Mundt, Steven S., Noonan, Heather, Nunes, Christian N., Olson, Steven H., Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M., Shah, Kashmira, Springer, Martin S., Strack, Alison M., Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B., Wright, Samuel D., Thieringer, Rolf
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212859/
https://ncbi.nlm.nih.gov/pubmed/16103409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050119
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