IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from peripheral blood mononuclear cells (PBMC). Furthermore, in vivo blockade of endogenous IL-23 activity by treatment with anti-IL-23 antibody attenuates collagen-induced arthritis in rats by preventing both inf...

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Bibliografiske detaljer
Main Authors: Yago, Toru, Nanke, Yuki, Kawamoto, Manabu, Furuya, Takefumi, Kobashigawa, Tsuyoshi, Kamatani, Naoyuki, Kotake, Shigeru
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212562/
https://ncbi.nlm.nih.gov/pubmed/17888176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2297
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