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A Nongenomic Mechanism for Progesterone-mediated Immunosuppression: Inhibition of K(+) Channels, Ca(2+) Signaling, and Gene Expression in T Lymphocytes
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and reversibly blocks voltage-gated and calcium-activ...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
1998
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212508/ https://ncbi.nlm.nih.gov/pubmed/9802971 |
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