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c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

The c-maf protooncogene is a T helper cell type 2 (Th2)-specific transcription factor that activates the interleukin (IL)-4 promoter in vitro. Although it has been postulated that c-maf directs the Th2-specific expression of the IL-4 gene in vivo, direct evidence that c-maf functions during the diff...

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Autors principals: Ho, I-Cheng, Lo, David, Glimcher, Laurie H.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212398/
https://ncbi.nlm.nih.gov/pubmed/9815263
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