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Massive Thymic Deletion Results in Systemic Autoimmunity through Elimination of CD4(+) CD25(+) T Regulatory Cells
Incomplete deletion of KRN T cells that recognize the ubiquitously expressed self-antigen glucose-6-phosphate-isomerase (GPI) initiates an anti-GPI autoimmune cascade in K/BxN mice resulting in a humorally mediated arthritis. Transgenic (Tg) expression of a KRN T cell receptor (TCR) agonist under th...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211803/ https://ncbi.nlm.nih.gov/pubmed/14744995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031137 |
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