Breaking Tolerance to Double Stranded DNA, Nucleosome, and Other Nuclear Antigens Is Not Required for the Pathogenesis of Lupus Glomerulonephritis

In lupus-prone NZM2328 mice, a locus Cgnz1 on chromosome 1 was linked to chronic glomerulonephritis, severe proteinuria, and early mortality in females. A locus Adnz1 on chromosome 4 was linked to antinuclear antibody (ANA) and anti–double stranded DNA (dsDNA) antibody (Ab) production. In this inves...

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Bibliographic Details
Main Authors: Waters, Samuel T., McDuffie, Marcia, Bagavant, Harini, Deshmukh, Umesh S., Gaskin, Felicia, Jiang, Chao, Tung, Kenneth S.K., Fu, Shu Man
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211766/
https://ncbi.nlm.nih.gov/pubmed/14718514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031519
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