Disrupted Dentate Granule Cell Chloride Regulation Enhances Synaptic Excitability during Development of Temporal Lobe Epilepsy

GABA(A) receptor-mediated inhibition depends on the maintenance of intracellular Cl(−) concentration ([Cl(−)](in)) at low levels. In neurons in the developing CNS, [Cl(−)](in) is elevated, E(GABA) is depolarizing, and GABA consequently is excitatory. Depolarizing GABAergic synaptic responses may be...

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Main Authors: Pathak, Hemal R., Weissinger, Florian, Terunuma, Miho, Carlson, Gregory C., Hsu, Fu-Chun, Moss, Stephen J., Coulter, Douglas A.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2007
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211568/
https://ncbi.nlm.nih.gov/pubmed/18094240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4390-07.2007
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