Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

BACKGROUND: Inhibition of vascular smooth muscle cell (vSMC) proliferation by oral anti-hyperglycemic agents may have a role to play in the amelioration of vascular disease in diabetes. Thiazolidinediones (TZDs) inhibit vSMC proliferation but it has been reported that they anomalously stimulate [(3)...

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Bibliographic Details
Main Authors: Little, Peter J, Osman, Narin, de Dios, Stephanie T, Cemerlang, Nelly, Ballinger, Mandy, Nigro, Julie
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211460/
https://ncbi.nlm.nih.gov/pubmed/17963526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-6-33
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