Opioid neuropeptide genotypes in relation to heroin abuse: Dopamine tone contributes to reversed mesolimbic proenkephalin expression

Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, relevant to addiction disorders. We examined polymorphisms of proenkephalin (PENK) and prodynorphin (PDYN) genes in relation to heroin abuse and gene expression in the human striatum and the relevance...

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Autori principali: Nikoshkov, Andrej, Drakenberg, Katarina, Wang, Xinyu, Horvath, Monika Cs., Keller, Eva, Hurd, Yasmin L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206614/
https://ncbi.nlm.nih.gov/pubmed/18184800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710902105
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