Structural basis for ligand-mediated mouse GITR activation

Glucocorticoid-induced TNF receptor ligand (GITRL) is a member of the TNF super family (TNFSF). GITRL plays an important role in controlling regulatory T cells. The crystal structure of the mouse GITRL (mGITRL) was determined to 1.8-Å resolution. Contrary to the current paradigm that all ligands in...

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Detalhes bibliográficos
Main Authors: Zhou, Zhaocai, Tone, Yukiko, Song, Xiaomin, Furuuchi, Keiji, Lear, James D., Waldmann, Herman, Tone, Masahide, Greene, Mark I., Murali, Ramachandran
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206589/
https://ncbi.nlm.nih.gov/pubmed/18178614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711206105
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