Identification of an altered peptide ligand based on the endogenously presented, rheumatoid arthritis-associated, human cartilage glycoprotein-39(263–275) epitope: an MHC anchor variant peptide for immune modulation

We sought to identify an altered peptide ligand (APL) based on the endogenously expressed synovial auto-epitope of human cartilage glycoprotein-39 (HC gp-39) for modulation of cognate, HLA-DR4-restricted T cells. For this purpose we employed a panel of well-characterized T cell hybridomas generated...

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Main Authors: Boots, Annemieke MH, Hubers, Henk, Kouwijzer, Milou, den Hoed-van Zandbrink, Leontien, Westrek-Esselink, Bernice M, van Doorn, Cindy, Stenger, Rachel, Bos, Ebo S, van Lierop, Marie-jose C, Verheijden, Gijs F, Timmers, Cornelis M, van Staveren, Catharina J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206373/
https://ncbi.nlm.nih.gov/pubmed/17645792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2269
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