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Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

BACKGROUND: Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy), and it is often associat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lentini, Laura, Amato, Angela, Schillaci, Tiziana, Di Leonardo, Aldo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206046/
https://ncbi.nlm.nih.gov/pubmed/17999753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-7-212
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