Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl–CoA reductase

3-hydroxy-3-methylglutaryl–CoA (HMG-CoA) reductase is the rate-limiting enzyme and the first committed step in the biosynthesis of cholesterol in mammals. We have determined the crystal structures of two nonproductive ternary complexes of HMG-CoA reductase, HMG-CoA/NAD(+) and mevalonate/NADH, at 2.8...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Tabernero, Lydia, Bochar, Daniel A., Rodwell, Victor W., Stauffacher, Cynthia V.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22040/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10377386/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.13.7167
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