Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions

Recent computational scans for non-coding RNAs (ncRNAs) in multiple organisms have relied on existing multiple sequence alignments. However, as sequence similarity drops, a key signal of RNA structure—frequent compensating base changes—is increasingly likely to cause sequence-based alignment methods...

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Detalhes bibliográficos
Main Authors: Torarinsson, Elfar, Yao, Zizhen, Wiklund, Eric D., Bramsen, Jesper B., Hansen, Claus, Kjems, Jørgen, Tommerup, Niels, Ruzzo, Walter L., Gorodkin, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203622/
https://ncbi.nlm.nih.gov/pubmed/18096747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.6887408
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