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Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection

An effective vaccine for genital herpes has been difficult to achieve because of the limited efficacy of subunit vaccines and the safety concerns about live viruses. As an alternative approach, mutant herpes simplex virus strains that are replication-defective can induce protective immunity. To incr...

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Detalhes bibliográficos
Main Authors: Da Costa, Xavier J., Jones, Cheryl A., Knipe, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22033/
https://ncbi.nlm.nih.gov/pubmed/10359827
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