Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

Oxidized low density lipoprotein (LDL) is a key factor in the pathogenesis of atherosclerosis and its thrombotic complications, such as stroke and myocardial infarction. It activates endothelial cells and platelets through mechanisms that are largely unknown. Here, we show that lysophosphatidic acid...

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Bibliografiske detaljer
Main Authors: Siess, Wolfgang, Zangl, Konrad J., Essler, Markus, Bauer, Markus, Brandl, Richard, Corrinth, Carolin, Bittman, Robert, Tigyi, Gabor, Aepfelbacher, Martin
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22019/
https://ncbi.nlm.nih.gov/pubmed/10359816
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