Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function

Tumor growth induced a significant increase of myeloid-derived suppressor cells (MDSCs) in the tumor-bearing host. In our previous study, we showed that MDSCs induced tumor-specific T-cell tolerance and the development of T regulatory cells (Tregs). Tumor-derived factors have been implicated in the...

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Autors principals: Pan, Ping-Ying, Wang, George X., Yin, Bingjiao, Ozao, Junko, Ku, Teresa, Divino, Celia M., Chen, Shu-Hsia
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200807/
https://ncbi.nlm.nih.gov/pubmed/17885078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-086835
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