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Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity

Mercuric chloride (HgCl(2)) induces a T cell-dependent autoimmune syndrome in Brown-Norway (BN) rats characterized by a humoral response, tissue injury with an accumulation of CD8(+) and CD4(+) T cells, and an increase in tissue IL-4 mRNA and serum IgE suggesting Th2 cell activation. In other models...

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Detalhes bibliográficos
Main Authors: KIELY, P D W, O'BRIEN, D, OLIVEIRA, D B G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200572/
https://ncbi.nlm.nih.gov/pubmed/8918574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1996.d01-855.x
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