CD4(+) T lymphocytes injected into severe combined immunodeficient (SCID) mice lead to an inflammatory and lethal bowel disease

Transfer of 2 × 10(5) congenic or semiallogenic purified TCRαβ(+) CD4(+) T cells to SCID mice leads to an infiltration of the recipient gut lamina propria and epithelium with a donor-derived CD4(+) T cell subset which induces a lethal inflammatory bowel disease (IBD) in the recipients. In contrast,...

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Detalhes bibliográficos
Main Authors: CLAESSON, M H, RUDOLPHI, A, KOFOED, S, POULSEN, S S, REIMANN, J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1996
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200450/
https://ncbi.nlm.nih.gov/pubmed/9099935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1996.48757.x
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