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βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier

β-Spectrin and ankyrin are major components of the membrane cytoskeleton. We have generated mice carrying a null mutation in the βIV-spectrin gene using gene trapping in embryonic stem cells. Mice homozygous for the mutation exhibit tremors and contraction of hindlimbs. βIV-spectrin expression is mo...

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Detalles Bibliográficos
Main Authors: Komada, Masayuki, Soriano, Philippe
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2002
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199236/
https://ncbi.nlm.nih.gov/pubmed/11807096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200110003
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