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Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool

The tyrosine kinase Syk has been implicated as a key signal transducer from the B cell antigen receptor (BCR). We show here that mutation of the Syk gene completely blocks the maturation of immature B cells into recirculating cells and stops their entry into B cell follicles. Furthermore, using radi...

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Detalhes bibliográficos
Principais autores: Turner, Martin, Gulbranson-Judge, Adam, Quinn, Marian E., Walters, Alice E., MacLennan, Ian C.M., Tybulewicz, Victor L.J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199169/
https://ncbi.nlm.nih.gov/pubmed/9396770
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