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Signaling Efficiency of the T Cell Receptor Controlled by a Single Amino Acid in the β Chain Constant Region

A single amino acid residue, Gln(136), located within the connecting peptide domain of Cβ controls the ability of the α/β TCR to transmit a full signal. TCRs in which this Cβ residue is mutated to Phe, the residue found in TCR-γ, are unresponsive to antigenic ligands. Interestingly, this Cβ residue...

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Autori principali: Bäckström, B. Thomas, Hausmann, Barbara T., Palmer, Ed
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199154/
https://ncbi.nlm.nih.gov/pubmed/9382891
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