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Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice

To investigate the role of T cell–mediated, perforin-dependent cytotoxicity in autoimmune diabetes, perforin-deficient mice were backcrossed with the nonobese diabetes mouse strain. It was found that the incidence of spontaneous diabetes over a 1 yr period was reduced from 77% in perforin +/+ contro...

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Main Authors: Kägi, David, Odermatt, Bernhard, Seiler, Peter, Zinkernagel, Rolf M., Mak, Tak W., Hengartner, Hans
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 1997
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199062/
https://ncbi.nlm.nih.gov/pubmed/9314549
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