Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

The dual specific kinase SAPK/ERK1 kinase (SEK1; mitogen-activated protein kinase kinase 4/Jun NH(2) terminal kinase [ JNK] kinase) is a direct activator of stress-activated protein kinases ([SAPKs]/JNKs) in response to CD28 costimulation, CD40 signaling, or activation of the germinal center kinase....

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Autors principals: Nishina, Hiroshi, Bachmann, Martin, Oliveira-dos-Santos, Antonio J., Kozieradzki, Ivona, Fischer, Klaus D., Odermatt, Bernhard, Wakeham, Andrew, Shahinian, Arda, Takimoto, Hiroaki, Bernstein, Alan, Mak, Tak W., Woodgett, James R., Ohashi, Pamela S., Penninger, Josef M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1997
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199046/
https://ncbi.nlm.nih.gov/pubmed/9294148
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