Potential Immunocompetence of Proteolytic Fragments Produced by Proteasomes before Evolution of the Vertebrate Immune System

To generate peptides for presentation by major histocompatibility complex (MHC) class I molecules to T lymphocytes, the immune system of vertebrates has recruited the proteasomes, phylogenetically ancient multicatalytic high molecular weight endoproteases. We have previously shown that many of the p...

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Main Authors: Niedermann, Gabriele, Grimm, Rudolf, Geier, Elke, Maurer, Martina, Realini, Claudio, Gartmann, Christoph, Soll, Jürgen, Omura, Satoshi, Rechsteiner, Martin C., Baumeister, Wolfgang, Eichmann, Klaus
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1997
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2198974/
https://ncbi.nlm.nih.gov/pubmed/9221750
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