Comprehensive Structural Organization of the Anaphase Promoting Complex Bound to the Mitotic Activator Slp1 Determined by Cryo-Electron Microscopy

The anaphase promoting complex/cyclosome (APC/C) is a conserved multi-subunit E3 ubiquitin ligase required to signal the degradation of key cell cycle regulators. Using single particle cryo-electron microscopy (cryo-EM) we have determined a three-dimensional (3D) structure of the core APC/C from Sch...

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Hoofdauteurs: Ohi, Melanie D., Feoktistova, Anna, Ren, Liping, Yip, Calvin, Cheng, Yifan, Chen, Jun-Song, Yoon, Hyun-Joo, Wall, Joseph S., Haung, Zhong, Penczek, Pawel A., Gould, Kathleen L., Walz, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2197158/
https://ncbi.nlm.nih.gov/pubmed/18082611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.10.003
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