A small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiency

A hammerhead ribozyme has been localized to the yeast nucleolus by using the U3 small nucleolar RNA as a carrier. The hybrid small nucleolar RNA:ribozyme, designated a “snorbozyme,” is metabolically stable and cleaves a target U3 RNA with nearly 100% efficiency in vivo. This is the most efficient in...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Samarsky, Dmitry A., Ferbeyre, Gerardo, Bertrand, Edouard, Singer, Robert H., Cedergren, Robert, Fournier, Maurille J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359759/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6609
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