QR Code

The Streptococcal Exotoxin Streptolysin O Activates Mast Cells To Produce Tumor Necrosis Factor Alpha by p38 Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Pathways

Streptolysin O (SLO), a major virulence factor of pyogenic streptococci, binds to cholesterol in the membranes of eukaryotic cells and oligomerizes to form large transmembrane pores. While high toxin doses are rapidly cytocidal, low doses are tolerated because a limited number of lesions can be rese...

Full description

Saved in:
Published in:Infect Immun
Main Authors: Stassen, Michael, Müller, Christian, Richter, Christoph, Neudörfl, Christine, Hültner, Lothar, Bhakdi, Sucharit, Walev, Iwan, Schmitt, Edgar
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2003
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC219607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14573633/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.11.6171-6177.2003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items