The Streptococcal Exotoxin Streptolysin O Activates Mast Cells To Produce Tumor Necrosis Factor Alpha by p38 Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Pathways

Streptolysin O (SLO), a major virulence factor of pyogenic streptococci, binds to cholesterol in the membranes of eukaryotic cells and oligomerizes to form large transmembrane pores. While high toxin doses are rapidly cytocidal, low doses are tolerated because a limited number of lesions can be rese...

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Pubblicato in:	Infect Immun
Autori principali:	Stassen, Michael, Müller, Christian, Richter, Christoph, Neudörfl, Christine, Hültner, Lothar, Bhakdi, Sucharit, Walev, Iwan, Schmitt, Edgar
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Molecular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC219607/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14573633/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.11.6171-6177.2003
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