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Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4(+) T Cells

Interleukin (IL)-4 is the most potent factor that causes naive CD4(+) T cells to differentiate to the T helper cell (Th) 2 phenotype, while IL-12 and interferon γ trigger the differentiation of Th1 cells. However, the source of the initial polarizing IL-4 remains unclear. Here, we show that IL-6, pr...

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Autors principals: Rincón, Mercedes, Anguita, Juan, Nakamura, Tetsuo, Fikrig, Erol, Flavell, Richard A.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196041/
https://ncbi.nlm.nih.gov/pubmed/9053446
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