CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

The structurally related T cell surface molecules CD28 and CTLA-4 interact with cell surface ligands CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells (APC) and modulate T cell antigen recognition. Preliminary reports have suggested that CD80 binds CTLA-4 and CD28 with affinities (K (d) values...

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Main Authors: van der Merwe, P.  Anton, Bodian, Dale L., Daenke, Susan, Linsley, Peter, Davis, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1997
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196039/
https://ncbi.nlm.nih.gov/pubmed/9053440
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