The Human Immunodeficiency Virus Type 1 Accessory Protein Vpu Induces Apoptosis by Suppressing the Nuclear Factor κB–dependent Expression of Antiapoptotic Factors

Human immunodeficiency virus (HIV) type 1 Vpu is an integral membrane protein with a unique affinity for βTrCP (TrCP), a key member of the SkpI-Cullin-F-box E3 ubiquitin ligase complex that is involved in the regulated degradation of cellular proteins, including IκB. Remarkably, Vpu is resistant to...

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Main Authors: Akari, Hirofumi, Bour, Stephan, Kao, Sandra, Adachi, Akio, Strebel, Klaus
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2001
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195969/
https://ncbi.nlm.nih.gov/pubmed/11696595
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