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Eliciting the Low-Activity Aldehyde Dehydrogenase Asian Phenotype by an Antisense Mechanism Results in an Aversion to Ethanol

A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2–2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol...

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Detalhes bibliográficos
Main Authors: Garver, Eric, Tu, Guang-chou, Cao, Qing-Na, Aini, Maria, Zhou, Feng, Israel, Yedy
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195938/
https://ncbi.nlm.nih.gov/pubmed/11535626
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