Immunoglobulin Heavy Chain Variable Region Gene Replacement as a Mechanism for Receptor Revision in Rheumatoid Arthritis Synovial Tissue B Lymphocytes

Mature B cells can alter their antibody repertoires by several mechanisms, including immunoglobulin heavy chain variable region (V(H)) replacement. This process changes the antigen combining site by replacing a portion of the original V(H)/diversity/heavy chain joining region (V(H)DJ(H)) rearrangeme...

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Autors principals: Itoh, Kenji, Meffre, Eric, Albesiano, Emilia, Farber, Andrew, Dines, David, Stein, Peter, Asnis, Stanley E., Furie, Richard A., Jain, Rita I., Chiorazzi, Nicholas
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2000
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195868/
https://ncbi.nlm.nih.gov/pubmed/11034605
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